Sleep Research

This study describes how Atlantia designed and conducted a human clinical trial to investigate the outcome of probiotic supplementation in sleep quality and its implications on immunity.

Recent studies have shown that circadian clock misalignment, sleep deprivation, and shift experience may change the circadian clock gene expression and microbial community structure. Given that sleep disturbance/loss is a significant factor that contributes to cognitive impairment, affective disruption, and physical disease; developing effective and safe treatments for disturbed sleep is a vital public priority.

The relationship between probiotics and sleep is still largely misunderstood due to a lack of data from large clinical trials illustrating the beneficial effects of probiotics in improving sleep quality in the general population; similarly, whether immune, metabolic and stress related biomarkers are significantly different in people with poor sleep quality.

The sponsor needed a trusted partner with the capabilities to access the required study population, with enough expertise to design and conduct a gold-standard trial with probiotics to investigate changes in:

• Objective sleep quality, including sleep latency, efficiency, and wake episodes.

• Self-reported physical and mental health, blood biomarkers including inflammatory, hormonal, tryptophan and metabolic markers.

Sponsor & Volunteer Testimonials

“Extremely impressed on delivery of project... ”

“Updates were relevant and timely, I never felt that I wasnt informed properly. Extremely impressed on delivery of project during the COVID-19 pandemic. Clearly a lot of effort and work has been put in to making sure operations have been running as close to perfect as possible.”

- Nutrition Scientist at the largest producer of dairy products in Scandinavia

“very flexible and responsive, very transparent..."

"High quality work, expertise in nutritional intervention studies, very flexible and responsive, very transparent. Atlantia has a personal touch which makes working with you a lot of fun. It was assuring and great to see that the leadership are very knowledgeable and still very much involved in details of the work".

- Nutrition Manager at a global leader in collagen-based solutions

“Adaptability with trial design and inputs is great!"

"Adaptability with trial design and inputs is great! I expect them to be able to answer the questions I have and they always do."

- Head of Clinical and Regulatory Affairs at revolutionary company tackling diabetes, heart disease, and obesity

“I trust Atlantia in their capabilities...”

"I was satisfied of the service provided and I trust Atlantia in their capabilities to conduct successfully clinical trials. We have good previous experience together and I know Atlantia is always improving".

- Nutrition Research Manager at multinational functional ingredients company tackling bone health

“...expertise, way of working and customer friendliness... ”

"We expected (and got) solution-orientated answers in a suitable time frame, we appreciated the overall service of Atlantia (including the expertise, way of working and customer friendliness)"

- Nutrition Scientist at multinational functional ingredients company tackling body composition

“This disease would of taken another few years to diagnose...”

"Really great people to deal with!!! I have done a few trials and have found them exceptional at what they do. I completed a pill camera trial about 2 years ago. From doing so it was found I had Crohn's disease. This disease would of taken another few years to diagnose had I not done this trial."

- Volunteer who help us and took part in our Video Camera Endoscopy trial

“...very professional and friendly..."

"All the staff I have met have been very professional and friendly and the trials have been interesting, educational and ultimately beneficial to my health".

-Participant member of our volunteer database for trials

“...everything was explained perfectly”

"Very friendly staff and everything was explained perfectly, also they had to take bloods and I'm the biggest baby when it comes to needles, but I didn't even realise they were finished, they were that good."

-Volunteer who took part in our food bioavailability studies

“... treated me with respect ...”

"I thought that that the staff at Atlantia always treated me with the utmost respect and my health was always at the forefront."

Case Study

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Case Study Overview

Challenges and Objectives

Case Study Highlights

Study product

Study age group

+18

Primary endpoint

Study duration

8